NANCHANGMYCIN A
Dianemycin 1-sodium salt
CAS: 65101-87-3
Molecular Formula: C47H77NaO14
NANCHANGMYCIN A - Names and Identifiers
| Name | Dianemycin 1-sodium salt |
| Synonyms | CS-2194 NanchangMycin NANCHANGMYCIN A Dianemycin 1-sodium salt Nanchangmycin (Nanchangmycin A) (2S,4R,6E,8S)-8-[(2S,2'R,4'S,5R,5'S,7R,7'R,8R,9S,9'S,10'R)-9-Hydroxy-2,4',8,10'-tetramethyl-2'-[(2S,3S,5R,6R)-tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-9'-[[(2S,5S,6R)-tetrahydro-5-methoxy-6-methyl-2H-pyran-2-yl]oxy][2,7'-bi-1,6-dioxaspiro[4.5]dec]-7-yl]-2,4,6-trimethyl-5-oxo-6-nonenoic acid sodium salt |
| CAS | 65101-87-3 |
NANCHANGMYCIN A - Physico-chemical Properties
| Molecular Formula | C47H77NaO14 |
| Molar Mass | 889.09565 |
| Storage Condition | 2-8℃ |
| In vitro study | Nanchangmycin inhibits Gram-positive bacteria. Nanchangmycin is a natural product of bacterial origin that effectively inhibits ZIKV infection in a variety of cell types. Block the entry of ZIKV as well as DENV infection. |
| In vivo study | Nanchangmycin can be used as a poultry growth agent and can cure coccidiosis in chickens. |
NANCHANGMYCIN A - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.125 ml | 5.624 ml | 11.247 ml |
| 5 mM | 0.225 ml | 1.125 ml | 2.249 ml |
| 10 mM | 0.112 ml | 0.562 ml | 1.125 ml |
| 5 mM | 0.022 ml | 0.112 ml | 0.225 ml |
Last Update：2024-01-02 23:10:35
NANCHANGMYCIN A - Reference Information
| agricultural antibiotics | agricultural antibiotics are used in agriculture with antimicrobial bioactive substances. It is derived from the secondary metabolites produced by some organisms in the process of growth and reproduction. After Chemical separation and extraction, the effective components were obtained and named by structural identification. The discovery of penicillin, an antibiotic for medical use, by Fremin in 429, and the discovery of streptomycin by Waxman in 1944 greatly promoted the study of antibiotics for agricultural use. The research and application of agricultural antibiotics in China has been internationally influenced, and product development and academic research have been gradually carried out. In, Yin Yuyun, Chinese Academy of Agricultural Sciences, took the lead in screening out 5406 resistant bacteria from soil actinomycetes, it is used for crop growth promotion, disease prevention, freezing, drought prevention and improving fruit quality, etc., the effect is outstanding, 60~70 years in the national promotion, the area of thousands of hm2. In the 60 s, Neiliaosu and Povamycins were successively selected and successfully applied in production. Yin Yuyun is the initiator of agricultural antibiotic research in China. In the 60s of the 20th century, the Institute of Microbiology, Chinese Academy of Sciences has developed the rice blast Antibiotic S, Spring (spring), multi-resistant (multi-oxygen), in the control of rice blast, tobacco brown spot disease has a good effect. 70 ~ the mid-80's is the peak period of the development of agricultural antibiotics, has successfully developed jinggangmycin, gongzhingmycin, agricultural anti 120, wuyimycin, zhongshengmycin, ningnanmycin, golden brown, fungicide such as blight peptide has good control effect on diseases such as rice, fruit trees and vegetables. Among them, multi-effect tetracycline, jinggangmycin, Gongzhuling lingmycin has won the National Invention Award; In the aspect of antibiotic insecticides, the successful development of antibiotics in China are Nanchang, Meiling, liuyangmycin, huactomycin, etc, animal use of antibiotics in terms of molinomycin, madumycin, Yuanjiang fungi, such as humic acid. In the 90 s, the development of agricultural antibiotics began to introduce genetic engineering, cell engineering and other biotechnology, broaden the research field, in order to improve the quality of products a step forward. Streptomyces Nanchang is a new species of Streptomyces producing insecticidal antibiotics. It was isolated from the rhizosphere soil of Camellia oleifera in Jiangxi Agricultural University in 1978. Through the cooperation with Shanghai Institute of Materia Medica, Chinese Academy of Sciences, it is shown that the fermentation products of Streptomyces Nanchang can produce a variety of insecticidal active substances. By Thin layer chromatography, A, B, C, D4 components with strong insecticidal activity. Among them, the component A is A typical Polyether antibiotic, whose chemical structure is homogenous with that of the foreign-made borneomycin, which is named Nanchang MYCIN (N. A). nanchangmycin and meilingmycin are two antibiotics produced by Streptomyces Nanchang. Among them, the chemical structure and physical and chemical properties of Nanchang MYCIN were identified as homogenous with dia neomycin, which belongs to Polyether antibiotics and has a significant effect on the prevention and control of chicken coccidiosis. |
| preparation method | a method for producing Nanchang MYCIN by fermentation of Streptomyces Nanchang, including spore culture, seed tank culture, fermentation tank culture, extraction steps: 1) the Streptomyces Nanchang preserved in the sand tube was inoculated to the High's medium or bran agar medium for 10~20 days; 2) step 1) the spores of Streptomyces Nanchang obtained are inoculated into a seed tank containing the seed culture medium designed by the present invention and equipped with a stirring device for fermentation culture, and the fermentation culture conditions are as follows: Temperature: 25~35 ℃; ventilation: 1: 0.5-1: 1.5V/V; Stirring speed: 200-600 r/min; Incubation time 36-60 hours. 3) The Culture obtained in step 2) is further inoculated into a fermentation tank containing the culture medium designed by the present invention and equipped with a stirring device, and the fermentation culture conditions are as follows: inoculum 5 ~ 20% V/V; Temperature 25~35 ℃; Ventilation 1: 0.5~1.5V/V; Stirring speed 200~600 r/min; Fermentation time 90~140 hours, the fermentation can be carried out in the fermentation tank for many times, the fermentation time is 120~230 hours; 4) the fermentation broth obtained by Step 3) is filtered to obtain filtrate and filter cake; 5) extract the filter cake with methanol, ethanol, chloroform, dichloromethane, acetone or benzene to obtain leaching solution; 6) concentrate the leaching solution, and then extract the concentrated leaching solution with ethyl acetate or butyl acetate, to obtain oil; 7) after absorbing the oil with auxiliary materials, drying and grinding are carried out to obtain Nanchang MYCIN preparation |
| biological activity | Nanchangmycin is a Polyether antibiotic with a structure similar to that of Dianemycin, very effective against a broad spectrum of harmful nematodes and insects, and no effect on mammals and plants. |
| Target | Bacteria Zika virus |
Last Update：2024-04-09 20:45:29
Supplier List
Spot supply
Product Name: Dianemycin 1-sodium salt Visit Supplier Webpage Request for quotationCAS: 65101-87-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Dianemycin 1-sodium salt Visit Supplier Webpage Request for quotationCAS: 65101-87-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History